Anti Cardiolipin Antibodies Report Format

Pathology
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What is the Anti Cardiolipin Antibody Test?

The Anti Cardiolipin Antibody (aCL) test detects autoantibodies that target cardiolipin, a type of phospholipid found in cell membranes. These antibodies are associated with increased risk of blood clots, miscarriages, and autoimmune conditions like Antiphospholipid Syndrome (APS).

What is an Anti Cardiolipin Antibodies Report Format?

An aCL report measures the level of IgG and IgM antibodies against cardiolipin in the blood and categorizes the results to assist in diagnosing APS and other thrombotic disorders.

Tests Included in Anti Cardiolipin Antibodies Report

Test

Description

aCL IgG/IgM

Quantifies IgG and/or IgM antibodies targeting cardiolipin phospholipids.

Key Parts of an Anti Cardiolipin Antibodies Report

Key Part

Description

Antibody Class

Indicates IgG and/or IgM isotype tested.

Measured Value

Result provided in GPL units (IgG) or MPL units (IgM).

Reference Range

Classifies result as negative, low, medium, or high positive.

Interpretation

Provides clinical insight based on antibody level and symptoms.

Normal Range for Anti Cardiolipin Antibodies Report

Result

Value (GPL/MPL Units)

Negative

<12

Borderline

12–19

Positive (Low)

20–39

Positive (Moderate)

40–79

Positive (High)

≥80

Parameters to Consider in aCL Report

Parameter

Interpretation

IgG vs IgM

IgG is more strongly associated with clinical manifestations.

Persistent Positivity

Positive results confirmed 12 weeks apart support APS diagnosis.

Combined Testing

Often evaluated alongside anti-β2 glycoprotein I and lupus anticoagulant.

Risk Association

Moderate to high titers linked to thrombosis, stroke, and pregnancy loss.

Guidelines for Anti Cardiolipin Antibodies Report Format

Guideline

Description

Unit Usage

Report results in GPL/MPL units with clear reference categories.

Repeat Testing

Needed to confirm persistence in suspected APS.

Clinical Correlation

Results must be interpreted alongside symptoms and other lab markers.

What Do the Results Mean?

Result Type

Interpretation

Negative

No significant cardiolipin antibodies detected.

Borderline

Unclear; may need retesting based on symptoms.

Positive

Suggests autoimmune or thrombotic tendency; clinical evaluation recommended.

Anti Cardiolipin Antibodies Report Interpretation

Test

Interpretation

aCL IgG/IgM

Assesses autoimmune risk and thrombotic potential through detection of antiphospholipid antibodies; part of APS diagnostic criteria.

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