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What is a Differential Leucocyte Count (DLC) Test?
The Differential Leucocyte Count (DLC) Test analyzes a blood sample to determine the specific types of white blood cells present. White blood cells perform critical functions within the immune response system, and the DLC provides an exacting analysis of the different WBCs, neutrophils, lymphocytes, monocytes, eosinophils and basophils. The test is helpful in ascertaining the presence of infections, inflammatory processes, allergic reaction, and certain leukemias.
With the proportions of differing types of WBCs being counted, the DLC aids in analyzing the immune response, and helps in understanding the possible reasons for altered white blood cell counts. The shift in circulation pattern of WBCs may also suggest some defined medical conditions; for example, bacterial infection, viral infection, or disorders of the blood.
What is a Differential Leucocyte Count (DLC) Report Format?
A report on a Differential Leucocyte Count (DLC) outlines the results from the particular DLC test that was conducted, giving a comprehensive description of each category of white blood cells present in the sample and, hence, the blood. This report is useful in assessing immune status and allows for the diagnosis of a number of infections, inflammatory processes, or blood pathologies.
The report format typically includes:
Patient Information : Name, age, sex, and relevant medical history.
Test Name : Differential Leucocyte Count (DLC).
Test Results : The percentage of each type of white blood cell present in the blood sample.
Reference Ranges : Normal reference values for each type of white blood cell.
Interpretation : Physician's comments based on the test results.
Remarks : Additional notes, such as recommendations for further tests or treatments.
Tests Included in Differential Leucocyte Count (DLC) Report
Test
Description
Differential Leucocyte Count (DLC)
Provides a breakdown of the different types of white blood cells in the blood, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils.
Key Parts of a Differential Leucocyte Count (DLC) Report
Part
Description
Differential Count
The percentage of each type of white blood cell in the blood sample.
Test Results
Displays the individual percentages of each white blood cell type.
Reference Ranges
The normal percentage range for each type of white blood cell.
Interpretation
Commentary on whether the WBC distribution is normal or suggests a specific condition.
Normal Ranges for Differential Leucocyte Count (DLC)
Parameter
Normal Range
Neutrophils
40% - 70%
Lymphocytes
20% - 40%
Monocytes
2% - 8%
Eosinophils
1% - 4%
Basophils
0% - 1%
Parameters to Consider in a Differential Leucocyte Count (DLC) Report
Parameter
Interpretation
Neutrophils
High Neutrophils : Indicates bacterial infections or acute inflammation.
Low Neutrophils : Suggests viral infections, bone marrow disorders, or immunosuppression.
Lymphocytes
High Lymphocytes : Often seen in viral infections, lymphocytic leukemia, or chronic inflammation.
Low Lymphocytes : May indicate immunodeficiency, HIV, or bone marrow disorders.
Monocytes
High Monocytes : Suggests chronic infections, inflammatory conditions, or certain types of leukemia.
Low Monocytes : Could indicate bone marrow disorders or suppression.
Eosinophils
High Eosinophils : Often seen in allergic reactions, parasitic infections, or asthma.
Low Eosinophils : Generally considered normal or of no clinical significance.
Basophils
High Basophils : Can indicate allergic reactions, chronic inflammation, or certain types of leukemia.
Low Basophils : Usually of no clinical concern.
Differential Leucocyte Count (DLC) Report Format Guidelines
Ensure that the report includes the differential percentages for each type of white blood cell along with reference ranges for comparison.
Test results should be marked as "Normal" or "Abnormal," with explanations provided for any abnormalities.
The interpretation should explain whether the white blood cell distribution is within normal limits or indicates a specific condition such as infection, inflammation, or hematologic disorder.
Additional remarks should be added if there are concerns regarding other blood components or potential follow-up tests.
Tables should be used to clearly display test results, reference ranges, and interpretations.
Patient details and medical history should be included for context.
What Do the Results Imply?
Neutrophils : A high neutrophil count typically suggests a bacterial infection or acute inflammation. A low count may be seen in viral infections, bone marrow problems, or certain medications.
Lymphocytes : Elevated lymphocytes can indicate viral infections or some chronic conditions, whereas low levels might suggest immunodeficiency or bone marrow disorders.
Monocytes : Increased monocytes are often seen in chronic infections or inflammation. A low count may point to bone marrow suppression.
Eosinophils : A higher eosinophil count suggests allergic reactions or parasitic infections. Low levels are usually considered within normal limits.
Basophils : An elevated basophil count is linked to allergic responses or inflammation, and low levels generally don’t raise concern.
Low : Viral infections, bone marrow disorders, or immunosuppression.
Lymphocytes
High : Viral infections, lymphocytic leukemia, chronic inflammation.
Low : Immunodeficiency, HIV, bone marrow disorders.
Monocytes
High : Chronic infections, inflammation, leukemia.
Low : Bone marrow disorders or suppression.
Eosinophils
High : Allergies, parasitic infections, asthma.
Low : Generally no clinical significance.
Basophils
High : Allergic reactions, chronic inflammation, certain leukemias.
Low : Typically of no concern.
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